Accessing your data 

Welcome to LabKey Server for Hartigan-O'Connor lab at University of California, Davis.

For users and collaborators: please login to access server and data. If you need a login, please contact Dennis Hartigan-O'Connor.

You also should have received instructions and an R file to access your data directly. If you have questions, please contact Dennis.


Lab members 

Dennis Hartigan-O'Connor, M.D., Ph.D.

Title: Associate Professor
Email: dhartigan AT ucdavis DOT edu
Phone: 530-752-7358

Interests: Relationship between variable development of such immune cells and variable control over chronic infectious diseases. Interactions between the normal gut microflora, pathogenic organisms, and immune cells within the intestine.

Dennis Hartigan-O'Connor at UC Davis

Dennis Hartigan-O'Connor at UCSF


Gema Méndez Lagares, Ph.D.

Title: Posdoctoral Fellow
Email: gemendez AT ucdavis DOT edu
Phone: 530-754-6088

Interests: HIV/SIV infection

Kawthar Machmach, Ph.D.

Title: Posdoctoral Fellow
Email: kmachmach AT ucdavis DOT edu
Phone: 530-754-6088



Nicole Narayan

Title: PhD Candidate (Genetics)
Email: nrnarayan AT ucdavis DOT edu
Phone: 530-754-6088

Interests: Gut microbiota interactions with the adaptive immune system.


David Merriam

Title: PhD Candidate (Microbiology)
Email: dpmerriam AT ucdavis DOT edu
Phone: 530-754-6088

Interests: ILC dynamics in SIV infection, Viral Pathogenesis and Treatment.


Joseph Dutra

Title: Lab manager
Email: jdutra AT ucdavis DOT edu
Phone: 530-754-6088

Interests: Molecular biology of SIV, HIV and HCV infection


Justin Fontaine

Title: SRA
Email: jhfontaine AT ucdavis DOT edu
Phone: 530-754-6088

Interests: Immunology/Virology/Molecular Biology


Connie Chen

Title: Research Assistant 
Email: cochen AT ucdavis DOT edu
Phone: 530-754-6088

Interests: Immunology and Infectious Diseases


Former Members:

Gayane Malayan

Title: Undergraduate Researcher
Email: gamalayan AT ucdavis DOT edu
Phone: 530-754-6088



Michael Lostica

Title: Undergraduate Researcher
Email: mlostica AT ucdavis DOT edu
Phone: 530-754-6088



Steven Laing, D.V.M., Ph.D.

Former Title: Veterinary Pathologist/Postdoctoral Fellow
Current position: 

Jonathan Liu

Former Title: Junior Specialist
Current position: Student at Ross University School of Veterinary Medicine




Depletion of gut-resident CCR5+ cells for HIV cure strategies

Merriam DP, Chen C, Mendez-Lagares G, Rogers K, Michaels A, Yan J, Casaz P, Reimann K, Villenger F, Hartigan-O'Connor DJ.

AIDS Res Hum Retroviruses. 2017; Sep 17.

PMID: 28918646

Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge.

Baker CA, Swainson L, Lin DL, Wong S, Hartigan-O'Connor DJ, Lifson JD, Tarantal AF, McCune JM.

Science translational medicine. 2015; 7(300):300ra125.

PMID: 26268312

Persistent effects of early infant diet and associated microbiota on the juvenile immune system.

Narayan NR, Méndez-Lagares G, Ardeshir A, Lu D, Van Rompay KK, Hartigan-O'Connor DJ.

Gut microbes. 2015; 6(4):284-9.

PMID: 26177107; PMCID: PMC4615596

Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems.

Ardeshir A, Narayan NR, Méndez-Lagares G, Lu D, Rauch M, Huang Y, Van Rompay KK, Lynch SV, Hartigan-O'Connor DJ.

Science translational medicine. 2014; 6(252):252ra120. NIHMSID: NIHMS668449

PMID: 25186175; PMCID: PMC4362692

Monocyte activation by interferon-α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.

Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM.

The Journal of infectious diseases. 2014; 209(10):1602-12.

PMID: 24325966; PMCID: PMC3997582

IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.

Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM.

International immunology. 2013; 25(8):471-83.

PMID: 23657000; PMCID: PMC3720065

In search of an effective vaccine

Hartigan-O'Connor DJ.

HIV Specialist. 2012 December; 4:33-34.

SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment.

Hartigan-O'Connor DJ, Abel K, Van Rompay KK, Kanwar B, McCune JM.

Science translational medicine. 2012; 4(136):136ra69. NIHMSID: NIHMS420502

PMID: 22649090; PMCID: PMC3520607

Fundamentals of HIV Medicine 2012 Edition

Hartigan-O'Connor DJ, Deeks SG.

2012 ed. Young B, Hardy D, editors. Washington, D.C.: American Academy of HIV Medicine; 2012. Immunology.

Th17 cells and regulatory T cells in elite control over HIV and SIV.

Hartigan-O'Connor DJ, Hirao LA, McCune JM, Dandekar S.

Current opinion in HIV and AIDS. 2011; 6(3):221-7. NIHMSID: NIHMS591356

PMID: 21399494; PMCID: PMC4079838

Development of cytomegalovirus (CMV) immune recovery uveitis is associated with Th17 cell depletion and poor systemic CMV-specific T cell responses.

Hartigan-O'Connor DJ, Jacobson MA, Tan QX, Sinclair E.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2011; 52(3):409-17.

PMID: 21189271; PMCID: PMC3060886

Review of Genetic proof for the transient nature of the Th17 phenotype

Hartigan-O'Connor DJ, McCune JM.

[Internet]. Faculty of 1000 Biology2011 January. Available from:

The human fetal immune response to hepatitis C virus exposure in utero.

Babik JM, Cohan D, Monto A, Hartigan-O'Connor DJ, McCune JM.

The Journal of infectious diseases. 2011; 203(2):196-206.

PMID: 21288819; PMCID: PMC3071071

Review of Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue homing properties

Hartigan-O'Connor DJ, McCune JM.

[Internet]. Faculty of 1000 Biology2010 April. Available from:

Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression.

Hartigan-O'Connor DJ, Abel K, McCune JM.

The Journal of experimental medicine. 2007; 204(11):2679-92.

PMID: 17954571; PMCID: PMC2118477

Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells.

Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM.

Journal of immunological methods. 2007; 319(1-2):41-52.

PMID: 17173927

Functional correction of adult mdx mouse muscle using gutted adenoviral vectors expressing full-length dystrophin.

DelloRusso C, Scott JM, Hartigan-O'Connor D, Salvatori G, Barjot C, Robinson AS, Crawford RW, Brooks SV, Chamberlain JS.

Proceedings of the National Academy of Sciences of the United States of America. 2002; 99(20):12979-84.

PMID: 12271128; PMCID: PMC130572

Gutted adenoviral vector growth using E1/E2b/E3-deleted helper viruses.

Barjot C, Hartigan-O'Connor D, Salvatori G, Scott JM, Chamberlain JS.

The journal of gene medicine. 2002; 4(5):480-9.

PMID: 12221641

Efficient rescue of gutted adenovirus genomes allows rapid production of concentrated stocks without negative selection.

Hartigan-O'Connor D, Barjot C, Crawford R, Chamberlain JS.

Human gene therapy. 2002; 13(4):519-31.

PMID: 11874630

Generation and growth of gutted adenoviral vectors.

Hartigan-O'Connor D, Barjot C, Salvatori G, Chamberlain JS.

Methods in enzymology. 2002; 346:224-46.

PMID: 11883070

The dynamics of the T-cell antitumor response: chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally.

Kirk CJ, Hartigan-O'Connor D, Mulé JJ.

Cancer research. 2001; 61(24):8794-802.

PMID: 11751401

Immune evasion by muscle-specific gene expression in dystrophic muscle.

Hartigan-O'Connor D, Kirk CJ, Crawford R, Mulé JJ, Chamberlain JS.

Molecular therapy : the journal of the American Society of Gene Therapy. 2001; 4(6):525-33.

PMID: 11735336

T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine: augmentation of dendritic cell-based immunotherapy.

Kirk CJ, Hartigan-O'Connor D, Nickoloff BJ, Chamberlain JS, Giedlin M, Aukerman L, Mule JJ.

Cancer research. 2001; 61(5):2062-70.

PMID: 11280767

Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors.

Hauser MA, Robinson A, Hartigan-O'Connor D, Williams-Gregory DA, Buskin JN, Apone S, Kirk CJ, Hardy S, Hauschka SD, Chamberlain JS.

Molecular therapy : the journal of the American Society of Gene Therapy. 2000; 2(1):16-25.

PMID: 10899824

Replication of lengthened Moloney murine leukemia virus genomes is impaired at multiple stages.

Shin NH, Hartigan-O'Connor D, Pfeiffer JK, Telesnitsky A.

Journal of virology. 2000; 74(6):2694-702.

PMID: 10684285; PMCID: PMC111759

Developments in gene therapy for muscular dystrophy.

Hartigan-O'Connor D, Chamberlain JS.

Microscopy research and technique. 2000; 48(3-4):223-38.

PMID: 10679969

Improved production of gutted adenovirus in cells expressing adenovirus preterminal protein and DNA polymerase.

Hartigan-O'Connor D, Amalfitano A, Chamberlain JS.

Journal of virology. 1999; 73(9):7835-41.

PMID: 10438876; PMCID: PMC104313

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.

Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein JL, Ericson J.

Nature. 1999; 398(6728):622-7.

PMID: 10217145

Progress toward gene therapy of Duchenne muscular dystrophy.

Hartigan-O'Connor D, Chamberlain JS.

Seminars in neurology. 1999; 19(3):323-32.

PMID: 12194388

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.

Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS.

Development (Cambridge, England). 1998; 125(12):2213-21.

PMID: 9584121

The cDNA sequence of murine Nkx-2.2.

Hartigan DJ, Rubenstein JL.

Gene. 1996; 168(2):271-2.

PMID: 8654958

Longitudinal organization of the anterior neural plate and neural tube.

Shimamura K, Hartigan DJ, Martinez S, Puelles L, Rubenstein JL.

Development (Cambridge, England). 1995; 121(12):3923-33.

PMID: 8575293

Basic fibroblast growth factor increases the number of excitatory neurons containing glutamate in the cerebral cortex.

Vaccarino FM, Schwartz ML, Hartigan D, Leckman JF.

Cerebral cortex (New York, N.Y. : 1991). 1995; 5(1):64-78.

PMID: 7719131

Enhancement of antineoplastic activity of 5-fluorouracil in mice bearing colon 38 tumor by (6R)5,10-dideazatetrahydrofolic acid.

Pizzorno G, Davis SJ, Hartigan DJ, Russello O.

Biochemical pharmacology. 1994; 47(11):1981-8.

PMID: 7516657

Induction of immediate early genes by cyclic AMP in primary cultures of neurons from rat cerebral cortex.

Vaccarino FM, Hayward MD, Le HN, Hartigan DJ, Duman RS, Nestler EJ.

Brain research. Molecular brain research. 1993; 19(1-2):76-82.

PMID: 8103187

Showing: all messages
No messages




Alice Tarantal, Ph.D.: Department of Cell Biology and Human Anatomy, University of California, Davis

Satya Dandekar, Ph.D.: Department of Medical Microbiology & Immunology, University of California, Davis

Peter Barry, Ph.D.: Department of Medical Pathology and Laboratory Medicine and Center for Comparative Medicine, University of California, Davis

Ellen Sparger, D.V.M., Ph.D.: Department of Medicine and Epidemiology, University of California, Davis

Sungjin Kim, Ph.D.: Center for Comparative Medicine, University of California, Davis

Chin-Shang Li, Ph.D: Division of Biostatistics, Department of Public Health Sciences, University of California, Davis

Laurel Beckett, Ph.D.: Division of Biostatistics, Department of Public Health Sciences, University of California, Davis 

Koen Van Rompay, D.V.M., Ph.D.: California National Primate Research Center, University of California, Davis

Valerie Flaherman, M.D.: Department of Pediatrics, University of California, San Francisco

Susan Lynch, Ph.D: Department of Medicine, Gastroenterology, University of California, San Francisco

Steven Deeks, M.D.: Department of Medicine, University of California, San Francisco

James Ryan, M.D.: Department of Medicine, University of California, San Francisco

Mike McCune, M.D., Ph.D.: Division of Experimental Medicine, University of California, San Francisco

Mario Stevenson, Ph.D.: Division of Infectious Diseases, University of Miami Leonard M. Miller School of Medicine 

Christian Brander, Ph.D.: Institut de Recerca de la Sida - IrsiCaixa